Role of histone and DNA methylation in gene regulation

来源：百度知道 编辑：UC知道 时间：2024/05/30 15:53:45
Transcription is known to be regulated by given chromatin
states, distinguished as transcriptionally active euchromatin
and silent heterochromatin. In plants, silencing in
heterochromatin is associated with hypermethylation of DNA
and specific covalent modifications of histone H3. Several lines
of evidence have suggested that maintenance of DNA
methylation patterns at CG sequences is responsible for the
formation of stable and thus heritable activity states termed
epialleles. By contrast, histone modification and DNA
methylation outside CGs confer the flexibility of transcriptional
regulation necessary for plant development and adaptive
responses to the environment. Recent studies have refined our
understanding of the biological significance of and the
molecular mechanisms involved in the interplay between DNA
and histone H3 methylation.

转录是众所周知的受特定的染色质

各州，尊敬的转录活跃的常染色质

和异染色质沉默。在工厂，在沉默

异染色质相关的DNA甲基化

和具体的共价键修改组蛋白H3 。几个线

证据表明，维修的DNA

甲基化模式在协商小组序列负责

形成稳定的，因此遗传的活动状态称为

epialleles 。相比之下，组蛋白修饰和DNA

甲基化以外皮质颗粒赋予的灵活性，转录

必要的调控植物生长发育和适应性

应对环境问题。最近的研究改进我们的

了解生物学意义和

分子机制参与的DNA之间的相互作用

和组蛋白H3甲基化。