这期SCIENCE上提到的将小鼠一种体细胞转换成另一种体细胞的究竟是哪篇文章？

来源：百度知道 编辑：UC知道 时间：2024/05/27 13:03:46
In 2008, researchers achieved another milestone in cell reprogramming. In an elegant study in live mice, they prompted cells to make the leap directly from one mature cell into another--flouting the usual rule that development of cells is a one-way street.

看这篇SCIENCE VOL 321 29 AUGUST 2008

上面有介绍。原文在Nature 455, 627 - 632 (2 Oct 2008), doi: 10.1038/nature07314, Article

In vivo: reprogramming of adult pancreatic exocrine cells to beta-cells

Qiao Zhou, Juliana Brown, Andrew Kanarek, Jayaraj Rajagopal, Douglas A. Melton

SUMMARY: One goal of regenerative medicine is to instructively convert adult cells into other cell types for tissue repair and
regeneration. Although isolated examples of adult cell reprogramming are known, there is no general understanding of how
to turn one cell type into another in a controlled manner. Here, using a strategy of re-expressing key developmental
regulators in vivo, we identify a specific combination of three transcription factors (Ngn3 (also known as Neurog3) Pdx1 and
Mafa) that reprograms differentiated pancreatic exocrine cells in adult mice into cells that closely resemble b-cells. The
induced b-cells are indistinguishable from endo