应该怎么说才比较顺??

不用怎么改，就改两处即可

Depressed people may have negative attitudes to confront their problems; they changed their characteristics by being in that situation, which will not help for depressed people as well as deteriorating it sharply.

读一下，是不是通顺了？原意没变

患了忧郁症的人会用负面的行为去抗拒他们的问题。当他们在那种情况下时，他们的性格会改变，这种情形帮不了患了忧郁症的人，反而，它会急剧的使他们恶化。

抑郁的人在面对困难时可能会产生消极的态度；在那种情形下，他们会改变他们的个性，这不但对他们无益，而且还会使他们（的抑郁）迅速恶化。