What's wrong with you(用另一种方法表达)

what happen to you
what's the matter with you

What's the matter with you? /What's the matter.(后者地道一些,)
What has happened to you?/What happen?(一脸茫然的问,很地道)
What's up? (张靓颖那首歌,全称是What's going up? )
What's the trouble with you?
Any problem?(回答No problem.简洁地道)