你那里不舒服?用英语怎么说

What’s wrong with you?
What's the matter?
上面两个都可以的~
三楼的，你开玩笑，你那是Chinese English~

What' wrong with you？

what's wrong with you?
what's the matter?

where do you feel uncomfortable?

what's wrong with you?和what's the matter? 都可以的