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Journal of Antimicrobial Chemotherapy
Advance Access publication 6 December 2005
OXE β-lactamases in Acinetobacter:the story so far
Molecular Chemotherapy,Centre for Infectious Diseases,University of Edinburgh,The Chancellor's Buliding,49 Little France Crecent,Edinburgh,EH16 4SB,UK
The emergence of carbaoenem resistance in Acinetobacter baumannii has become a global concern since these β-lactams are often the only effectine treatment lsft against many multiresistant strains.A recent debelopmenth has the discovery of a novel group of narrow-spectrum OXA β-lactamases in carbapenem-resistant strains,some of whitch have acquired the ability to hydrolyse the carbapenems.The first of these was found in a strain isolated in Edinburgh before imipenem was in usr in the hospital.Whether these carbapenemases have been acquired or are part of the genetic make-up of this species has yet to be determined.More importantly,however,they represent an important stage in the evolut
Advance Access publication 6 December 2005
OXE β-lactamases in Acinetobacter:the story so far
Molecular Chemotherapy,Centre for Infectious Diseases,University of Edinburgh,The Chancellor's Buliding,49 Little France Crecent,Edinburgh,EH16 4SB,UK
The emergence of carbaoenem resistance in Acinetobacter baumannii has become a global concern since these β-lactams are often the only effectine treatment lsft against many multiresistant strains.A recent debelopmenth has the discovery of a novel group of narrow-spectrum OXA β-lactamases in carbapenem-resistant strains,some of whitch have acquired the ability to hydrolyse the carbapenems.The first of these was found in a strain isolated in Edinburgh before imipenem was in usr in the hospital.Whether these carbapenemases have been acquired or are part of the genetic make-up of this species has yet to be determined.More importantly,however,they represent an important stage in the evolut
《抗菌化学疗法》杂志上
2005年12月6日提前存取出版
在不OXEβ-lactamases:到目前为止
分子化疗,中心为传染性疾病,爱丁堡大学,议长,49岁的法国Crecent少、爱丁堡、EH16 4SB,英国
carbaoenem电阻的出现在鲍曼不动杆菌已成为全球关注这些β-lactams通常是唯一effectine对抗许多multiresistant菌株治疗lsft…最近的一debelopmenth已发现的一种β-lactamases仅OXA集团在carbapenem-resistant株,其中一些已经取得了hydrolyse能力的carbapenems第一个被发现在一株孤立在爱丁堡的药物有亚胺培南在使用之前在医院这些carbapenemases是否已经或正在部分的基因构成该物种还有待确定然而更重要的是,他们代表着一种重要阶段的抗生素耐药性的演化出不本文探讨了产生这些不寻常的酶在过去的十年。