UC知道Safety assessment of inhaled xylitol in subjects with cystic fibrosis 求翻译
来源：百度知道 编辑：UC知道 时间：2024/05/15 12:29:44
Background: Xylitol is a 5-carbon sugar that can lower the airway surface salt concentration, thus enhancing innate immunity. We tested the
safety and tolerability of aerosolized iso-osmotic xylitol in subjects with cystic fibrosis.
Methods: In this pilot study, 6 subjects with cystic fibrosis and an FEV1 >60% predicted underwent a baseline spirometry followed by
exposures to aerosolized saline (10 ml) and 5% xylitol (10 ml). Serum osmolarity and electrolytes were measured at baseline and after xylitol
exposure. Spirometry, oxygen saturation and respiratory symptom questionnaire using visual analog scale were tested at baseline and after
each exposure. Sputum for cytokine analysis was collected after saline and xylitol nebulizations.
Results: There was no change in FEV1 after xylitol exposure compared with baseline or normal saline exposure ( p =0.19). Laboratory
values and respiratory symptoms were not affected by xylitol inhalation. The mean IL-8
safety and tolerability of aerosolized iso-osmotic xylitol in subjects with cystic fibrosis.
Methods: In this pilot study, 6 subjects with cystic fibrosis and an FEV1 >60% predicted underwent a baseline spirometry followed by
exposures to aerosolized saline (10 ml) and 5% xylitol (10 ml). Serum osmolarity and electrolytes were measured at baseline and after xylitol
exposure. Spirometry, oxygen saturation and respiratory symptom questionnaire using visual analog scale were tested at baseline and after
each exposure. Sputum for cytokine analysis was collected after saline and xylitol nebulizations.
Results: There was no change in FEV1 after xylitol exposure compared with baseline or normal saline exposure ( p =0.19). Laboratory
values and respiratory symptoms were not affected by xylitol inhalation. The mean IL-8
背景：木糖醇是一种五碳糖，可降低呼吸道表面盐的浓度，从而提高先天免疫。我们测试了
安全性和耐受雾化异与囊性纤维化学科渗透木糖醇。
方法：在这个试验研究，6个科目的囊肿性纤维化和FEV1的“60％的预测进行了基线肺活量之后
在雾化液（10毫升）和5％木糖醇（10毫升）的风险。血清渗透压和电解质测定后，在基线和木糖醇
曝光。肺功能，血氧饱和度和呼吸道症状问卷采用视觉模拟评分进行了测试后，在基线和
每个接触。对细胞因子分析后痰液收集生理盐水和木糖醇nebulizations。
结果：无木糖醇曝光后FEV1的改变与基准或生理盐水接触性（P = 0.19）。实验室
价值观和呼吸道症状并没有受到木糖醇吸入。平均中IL - 8水平的痰用生理盐水类似
木糖醇的风险与3.5T 0.6纳克（3.5T0.5 /毫升）。
结论：对单剂量雾化吸入异渗木糖醇深受囊性纤维化科目不能容忍的。未来的研究
长期安全是必需的。