英文：你疯了吗、你有病吗（不是真的有病）、怎么说

Are you crazy?
Are you all right?
Something wrong?
这几个都可以的

我记得英文中要问别人是不是疯了，用insane的比较多，而这个词所含的贬义也较以上为甚：are you insane?

ARE YOU CRAZY?
ARE YOU ALL RIGHT?

Are you mad?

Are you crazy?
Do you have something wrong with your head?