____subject do you like best?填Which还是 What

填What。后面给定选择范围的疑问句最好用Which提问，选择范围不明确的提问最好以What起始。

which
你最喜欢哪一科？
which是哪一个， what是什么
根据意思选which

which表示哪一个
哪一科你最感兴趣

what 也可以，带指某个，FOR INSTANCE
What college are you attending? You should know what musical that song is from.
你在念什么大学?你应该知道哪首歌出自哪部音乐片

which

没有范围用what