帮忙翻译一下啊！！！急~~~

来源：百度知道 编辑：UC知道 时间：2024/05/15 17:49:30
One extension of this class of drugs that target HIFI-controlled genes is the use of HRE-driven suicide genes as gene therapy agents (Cowen et al., 2004). These agents utilize knowledge of genomic structure of the regulatory regions of hypoxia-inducible genes to engineer gene therapy vectors to deliver cytotoxic genes ,such as herpes simplex virus thymidine kinase (Shibata et al.,2002;Wang et al.,2005).These vectors contain multiple copies of HREs derived from the VEGF or EPO gene promoters and in some cases additional regulatory sequences. This type of approach is not limited to suicide constructs for the treatment of cancer; it has also been explored to deliver angiogenic factors to the ischemic heart in a hypoxia-inducible fashion (Su et al., 2002; Cowen et al., 2004).
翻译的句子要通顺啊~~

药物的这组一个引伸瞄准高保真受控基因是对HRE 被驾驶的自杀基因的用途作为基因疗法代理(Cowen 等2004) 。这些代理运用低氧症可诱导基因的管理地区的genomic 结构知识设计基因疗法传染媒介交付细胞毒素的基因, 譬如疱疹单工通信制病毒胸腺嘧啶脱氧核苷激酶(Shibata 等, 2002;Wang 等, 2005).These 传染媒介包含HREs 的多个拷贝从VEGF 或EPO 基因被获得促进者和在某些情况下另外的管理序列。这类型方法对自杀修建不被限制为癌症的治疗; 它并且被探索提供angiogenic 因素对局部缺血的心脏低氧症可诱导时尚(Su 等2002 年; Cowen 等, 2004) 。