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来源：百度知道 编辑：UC知道 时间：2024/06/15 17:12:42
ASFV is the sole member of the family Asfarviridae and the
only known DNA arbovirus (14, 38). ASFV is a large, icosahedral
virus that contains a linear double-stranded DNA genome
(170 to 190 kbp) encoding approximately 165 genes (50;
C. A. Balinsky et al., unpublished data). The availability of
complete ASFV genome sequences has revealed that, similar
to poxviruses, ASFVs encode proteins with functions essential
for viral replication, including those involving structure and
assembly of the virion and those responsible for biogenesis of
mRNA and DNA. A large number of ASFV genes are of
unknown function and may be involved in aspects of viral
virulence and host range (46, 50; Balinsky et al., unpublished).
Pathogenic ASFV genomes contain 11 to 15 multigene family
360 (MGF360) genes and either 9 or 10 multigene family
530 (MGF530) genes (Balinsky et al., unpublished). Recently,
we have identified MGF360 and MGF530
only known DNA arbovirus (14, 38). ASFV is a large, icosahedral
virus that contains a linear double-stranded DNA genome
(170 to 190 kbp) encoding approximately 165 genes (50;
C. A. Balinsky et al., unpublished data). The availability of
complete ASFV genome sequences has revealed that, similar
to poxviruses, ASFVs encode proteins with functions essential
for viral replication, including those involving structure and
assembly of the virion and those responsible for biogenesis of
mRNA and DNA. A large number of ASFV genes are of
unknown function and may be involved in aspects of viral
virulence and host range (46, 50; Balinsky et al., unpublished).
Pathogenic ASFV genomes contain 11 to 15 multigene family
360 (MGF360) genes and either 9 or 10 multigene family
530 (MGF530) genes (Balinsky et al., unpublished). Recently,
we have identified MGF360 and MGF530
asfv是唯一的家庭成员asfarviridae和已知的仅有的DNA虫媒( 14 , 38 ) . asfv是一个大型, icosahedral病毒含有一种线性双链基因组( 170至190元件)编码大约165个基因( 50个; C.A.Petri在balinsky et al . 未发表的数据) . 提供完整的asfv基因组序列已经发现,类似病毒, asfvs编码蛋白质的功能,对于病毒的复制, 包括涉及结构和集会的腿部和那些负责生源的mRNA及DNA . 一大批asfv基因是未知功能,可能涉及的方面,病毒毒及 寄主范围( 46名, 50岁; balinsky et al . , unpublished ) . asfv致病基因含有1911年至1915年multigene family 360 ( mgf360 )的基因,或是9日或10 multigene family 530 ( mgf530 )基因( balinsky et al . , unpublished ) . 最近, 我们已确定mgf360和mgf530基因作为新型巨寄主范围决定所需的高效增长的巨噬细胞( 54 ) . 0 感染巨细胞培养与mgf360 - mgf530 ( mgf360/530 )基因缺失突变pr4 35 ( 6 mgf360两mgf530基因缺失)导致 在2至3日志降低病毒滴度和早期细胞死亡,苏 ggesting直接或间接的作用这些基因在某些方面感染细胞存活( 54 ) (草zsak , un 已公布的数据) . 此外, 猪virulence determinant ( 2500 )含mgf360/530基因组图体内标记拯救左变 地区的asfv基因( 37 ) .