急求帮忙翻译!!!(18)(生物学)

来源：百度知道 编辑：UC知道 时间：2024/06/06 10:31:12
The inability of Pr435 to suppress an IFN response in
infected cells may account for its growth defect in macrophage
cell cultures. Pr435 exhibits a 100- to 1,000-fold growth defect
in macrophage cell cultures that is characterized by early
apoptotic cell death (54) (Zsak, unpublished). IFN-α has been
shown to inhibit ASFV replication in monocytes and alveolar
macrophages (16). IFN-induced antiviral cellular responses,
together with the potential for increased PKR activity in
Pr4△35-infected cells, may in part be responsible for the
growth defect and the apoptotic response. Increased apoptosis
of Pr4△35-infected cells may involve PKR or the IFN-induced
CARD domain-containing helicase gene. Increased expression
of the PKR activator gene PACT and decreased expression of
the inhibitor of PKR (P58) suggest that Pr435 infection may
affect PKR activity. PKR has a proapoptotic effect mediating
dsRNA- and virus-induc

The inability of Pr435 to suppress an IFN response in
infected cells may account for its growth defect in macrophage
cell cultures. Pr435 exhibits a 100- to 1,000-fold growth defect
in macrophage cell cultures that is characterized by early
apoptotic cell death (54) (Zsak, unpublished). IFN-α has been
shown to inhibit ASFV replication in monocytes and alveolar
macrophages (16). IFN-induced antiviral cellular responses,
together with the potential for increased PKR activity in
Pr4△35-infected cells, may in part be responsible for the
growth defect and the apoptotic response. Increased apoptosis
of Pr4△35-infected cells may involve PKR or the IFN-induced
CARD domain-containing helicase gene. Increased expression
of the PKR activator gene PACT and decreased expression of
the inhibitor of PKR (P58) suggest that Pr435 infection may
affect PKR activity. PKR has a proapoptotic effect mediating
dsRN