急求帮忙翻译!!!(19)生物学

来源：百度知道 编辑：UC知道 时间：2024/05/26 05:48:07
Pr4△35 exhibits a growth defect in vivo and is attenuated in
pigs (54) (Zsak et al., unpublished). The inability of Pr4△35 to
suppress an IFN response may be a significant factor in the
attenuated phenotype. Pr4△35 infection induces expression of
two known chemokines: MCP-1, a C-C-type chemokine that
attracts monocytes and promotes mast cell activation, and IP-
10, a CXC chemokine that attracts monocytes, T lymphocytes,
and NK cells and has the capacity to control viral replication
(15, 30, 35). Other Pr4△35-induced genes with a potential
impact on viral virulence and host range are the Mx protein
and IFN-induced TM-3. Mx proteins are IFN-regulated GTPbinding
proteins of the dynamin family that block influenza
virus mRNA synthesis in the nucleus (3, 24). TM-3 is a protein
highly inducible by IFN-α, -β, and -γ (11). Pr4△35 infection
induces expression of the proteolysis-related genes ISG15 and
ISG43. ISG15 induct

pr4△35呈现出增长的缺陷在体内衰减是猪( 54 ) ( zsak et al . , unpublished ) . 宠pr4△35压制了干扰素的反应可能是一个重要因素减毒7.40% . pr4△35感染诱导表达两种已知chemokines : MCP-1水平, 一个个C型趋化因子吸引单核细胞和促进肥大细胞活化,安- 10 , 一cxc chemokine吸引单核细胞, T淋巴细胞, NK细胞并有能力控制病毒的复制( 15 , 30 , 35 ) . 其他pr4△35 -诱导基因有可能影响病毒的致病性和宿主的Mx蛋白和干扰素诱导tm - 3 . Mx蛋白是干扰素调节gtpbinding蛋白质的dynamin family座流感病毒mRNA合成,在核( 3 , 24 ) . tm - 3是一种高蛋白质诱导干扰素α, -β, and -γ( 11 ) . pr4△35感染诱导表达的蛋白相关基因isg15和isg43 . isg15诱导是目前所知最早的反应I型干扰素, 而isg15是最强烈的诱导蛋白后干扰素治疗后或病毒感染后( 10 ) . isg15是一个17 kDa的泛素样蛋白的功能,结合其他蛋白质. 但也有人认为,这是涉及细胞间的信号, 可能是诱导干扰素-γ分泌的单核细胞和巨噬细胞( 10 ) . isg15分泌的单核细胞和淋巴细胞,并在最近已经表明,病毒可以抑制isg15功能 暗示可能的抗病毒功能是( 52 ) . isg43 ( ubiquitin加工蛋白酶43 )是一个isg15特异性加工蛋白酶,其职能是专门移除isg15从conjugated proteins ( 34 ) . 由于这是一个崭新asfv mgf360/530基因及其生物学意义上的病毒毒力和巨噬细胞的宿主范围 它将重要的是确定其功能是抑制干扰素的反应. .