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来源：百度知道 编辑：UC知道 时间：2024/06/21 15:00:39
Introduction
The routinely use of prophylactic antibiotic administration during fracture treatment is quite common. The beneficial effect of the prophylactic antibiotic administration was carried out in several studies, if antibiotics were given before skin incision [14, 20]. First-generation cephalosporins as cefazolin were most frequently used as prophylactic antibiotics, because they offered the best antimicrobiological activity against Staphylococcus strains, which were the most frequent bacterias in bone and soft tissue infections [13, 14, 20]. Several studies could demonstrate, that blood loss during standard operations probably affect serum and/or tissue concentrations. Therefore, an additional dose of cefazolin was recommended, if operation time exceeds 3 or 4 hours [1, 16, 21, 25, 26]. Patients with multiple trauma have often associated open or closed fractures and extended injuries to the soft tissue. Early stabilization of long-bone fractures in multiple-trauma pa
The routinely use of prophylactic antibiotic administration during fracture treatment is quite common. The beneficial effect of the prophylactic antibiotic administration was carried out in several studies, if antibiotics were given before skin incision [14, 20]. First-generation cephalosporins as cefazolin were most frequently used as prophylactic antibiotics, because they offered the best antimicrobiological activity against Staphylococcus strains, which were the most frequent bacterias in bone and soft tissue infections [13, 14, 20]. Several studies could demonstrate, that blood loss during standard operations probably affect serum and/or tissue concentrations. Therefore, an additional dose of cefazolin was recommended, if operation time exceeds 3 or 4 hours [1, 16, 21, 25, 26]. Patients with multiple trauma have often associated open or closed fractures and extended injuries to the soft tissue. Early stabilization of long-bone fractures in multiple-trauma pa
介绍
对预防疾病的抗药性管理的定期地用途在破裂治疗期间是相当共同的。 预防疾病的抗药性管理的有利作用在几项研究中被执行了，如果抗生素在皮肤切开[14， 20之前]被给了。 第一代头孢菌素作为cefazolin最频繁使用了作为预防疾病的抗生素，因为他们提供了最佳的antimicrobiological活动反对葡萄球菌张力，是最频繁的bacterias在骨头和软的组织传染[13， 14， 20]。 在标准操作影响清液和组织集中期间，几项研究能大概展示，那失血。 所以，推荐了cefazolin另外的药量，如果操作时间超出3个或4个小时[1， 16， 21， 25， 26]。 有多精神创伤的病人经常同开放或闭合的破裂和延长的伤害联系在一起对软的组织。 长骨头破裂的早期安定在多精神创伤患者能避免器官官能不良综合症状，肺复杂化和缩短透气[4， 5的]时期。 如果患者与唯一开放矿石闭合的破裂从预防疾病的抗药性管理赢利，多精神创伤患者可能也受益于1 Klinik und Poliklinik für Unfallchirurgie (主任： D. Nast- Kolb)，埃森教授， 博士，德国。