He asks her ,what is wrong with you?合并为一句

He asks her ,what is wrong with you?
后边这句话是一种特殊情况，作宾语从句时，时态可以变，语序一定要保持不变。但鉴于主句为一般时态，
所以，正确做法应该是：He asks her what is wrong with her.

He asks her （that）what wrong is with her
从句是用陈述句态.
that可加可不加 但习惯用法是加.使得句式明朗些..

He asks her what's wrong with you.

正确的应该是:he asks her what was wrong.

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He asks her what is wrong with her.

He asks what wrong with her.