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来源：百度知道 编辑：UC知道 时间：2024/06/08 07:34:33
Like bone marrow stromal cells,adipose tissue-derivedstem cells(ADSCs) possess multlineage potential,a capacity for self-renewal
and long-term viability.To confirm whether ADSCs represent a pro-
mising,the osteogenic potential of ADSCs under the control of ce-rtain osteoinductive genes has been evaluated.Runx2,a transcript-
ion factor at the downstream end of bone morphogenetic protein(BMP) signaling pathways,is essential for osteoblast differentia-tion and bone formation .In this study we used adenovirus vector to deliver Runx2 to ADSCs and then examined the enhancement of
osteogenic activity.Overexpression of Runx2 inhibited adipogenesis ,as demonstrated by suppression of LPL and PPARγ
expression at the mRNA level and reduced lipid droplet formation
.Moreover,ADSCs transduced with AdRunx2 underwent rapid and marked osteoblast differentiation as determined by osteoblastic
gene expression ,alkaline phosphatase activity and mineral
deposition
and long-term viability.To confirm whether ADSCs represent a pro-
mising,the osteogenic potential of ADSCs under the control of ce-rtain osteoinductive genes has been evaluated.Runx2,a transcript-
ion factor at the downstream end of bone morphogenetic protein(BMP) signaling pathways,is essential for osteoblast differentia-tion and bone formation .In this study we used adenovirus vector to deliver Runx2 to ADSCs and then examined the enhancement of
osteogenic activity.Overexpression of Runx2 inhibited adipogenesis ,as demonstrated by suppression of LPL and PPARγ
expression at the mRNA level and reduced lipid droplet formation
.Moreover,ADSCs transduced with AdRunx2 underwent rapid and marked osteoblast differentiation as determined by osteoblastic
gene expression ,alkaline phosphatase activity and mineral
deposition
如骨髓基质干细胞,脂肪细胞derivedstem (泭)具备multlineage潜力,有能力自我更新能力和长期viability.to确认是否代表泭 亲搅拌,纤维环泭控制下的铈骨软骨基因已evaluated.runx2 ,转录因子离子 在下游底骨形态发生蛋白( BMP )信号通路,对成骨细胞分化增殖和骨形成. 在本研究 我们用腺病毒载体运送结合因子对脂肪,然后审查增强骨activity.overexpression的抑制因子1 脂,具体表现为抑制脂酶和PPARγ 表达在mRNA水平和减少脂滴形成. 此外,泭转adrunx2经历了迅速和明显的成骨细胞分化 由成骨细胞的基因表达,碱性磷酸酶活性及矿物沉积. 此外,组织学检查显示植入因子1改性脂肪可引起矿物沉积和骨样组织形成vivo.these 结果证实,第一能力的结合因子促进成骨细胞分化,其次权限泭作为靶细胞 骨组织工程. 我们的工作,显示了潜在的新方法,为骨修复runx2modified泭骨组织 工程学.