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Congestive heart failure is a common clinical syndrome. Patients with congestive heart failure plasma B-type natriuretic peptide, BNP significantly increase its plasma can be used as markers for the diagnosis of heart failure, the severity of the judgment, clinical treatment and prognosis assessment. Exogenous brain natriuretic peptide can significantly improve acute decompensated heart failure symptoms, related drugs already available. The efficacy of the treatment has now been confirmed, but the treatment also can cause serious adverse consequences, as to whether the drug in clinical trials to promote large-scale need prospective randomized double-blind basis for the evidence-based medicine.