关于Zn的中英文对照资料

Evidence that the beta-amyloid plaques of Alzheimer's disease
represent the redox-silencing and entombment of abeta by zinc.

Cuajungco MP, Goldstein LE, Nunomura A, Smith MA, Lim JT, Atwood CS,
Huang X, Farrag YW, Perry G, Bush AI.

Laboratory for Oxidation Biology, Genetics and Aging Unit,
Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

Abeta binds Zn(2+), Cu(2+), and Fe(3+) in vitro, and these metals are
markedly elevated in the neocortex and especially enriched in amyloid
plaque deposits of individuals with Alzheimer's disease (AD). Zn(2+)
precipitates Abeta in vitro, and Cu(2+) interaction with Abeta
promotes its neurotoxicity, correlating with metal reduction and the
cell-free generation of H(2)O(2) (Abeta1-42 > Abeta1-40 >
ratAbeta1-40). Because Zn(2+) is redox-inert, we studied the
possibility that it may play an inhibitory role in H(2)O(2)-media