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来源：百度知道 编辑：UC知道 时间：2024/06/19 04:59:00
many possible mechanisms, the simplest of which is likely to be through binding onto specific receptors inside cells. Hormone receptors are situated on nuclear or other membranes and act as molecular switches controlling the transcription of genetic material and through this the metabolic activity of the cell. Endocrine disruptors can either switch hormone receptors on or off through binding to the operational site of the receptor. The relationship between dose and response for each mechanism is likely to be different and so a thorough understanding of the mechanism of action is necessary before the effects of endocrine disruptors can be predicted. Risk assessment needs to take into account the possible additive effects of compounds and influences during critical development windows.
5.2.9 Carcinogenic risk assessment
The risk assessment of carcinogenic chemicals differs from the assessment of nun-carcinogenic chemicals as a policy assumption is
made that carcinogens h
5.2.9 Carcinogenic risk assessment
The risk assessment of carcinogenic chemicals differs from the assessment of nun-carcinogenic chemicals as a policy assumption is
made that carcinogens h
许多可能的机制，最简单的，其中很可能是通过具有约束力的具体到受体细胞内。激素受体的是坐落于核物质或其他膜，并作为分子开关控制转录的遗传物质，并通过这一代谢活性的细胞。内分泌干扰物可以切换激素受体的开或关，通过有约束力的，以业务网站的受体。之间的关系，剂量和反应机制，为每个可能有所不同，所以深入了解的机制，有必要采取行动之前，影响内分泌干扰物是可以预测的。风险评估需要考虑到可能的加性效应的化合物和影响力在关键的发展窗口。
5.2.9致癌风险评估
风险评估致癌的化学品不同的评估尼姑致癌化学品作为一种政策的假设是
提出致癌物没有门槛
剂量。暴露于任何级别的致癌物质
可能会导致不良影响人类。这个
是支持的证据表明，不可逆转的自我复制的病变可能会导致从一个突变，在一个单一的体细胞以下政府一个单一的多斯特。 0pponents这种看法，认为它有可能用于人体进行代谢解毒就接触低剂量。监管的目的，不过，可能有必要保护所有个人，这包括那些其有效的阈值水平，可能是零，为某一特定致癌物质。因为不确定性，在引用的应用门槛的概念，致癌物质的，复杂的数学模型已经开发了模型低剂量的反应