UC知道英语翻译(4)
来源：百度知道 编辑：UC知道 时间：2024/06/17 20:43:53
The reaction of propylene oxide with amines such as 16–19). The ring opening of cyclohexene oxide was also
aniline, 2-fluoroaniline, p-anisidine and indoline afforded successfully achieved giving 90–92% yields of the desired
good yields with complete regioselectivity (entries 8–11). Chemoselective aminolysis of epichlorohydrin wasobserved, with desired product resulting from attack atthe less substituted carbon on the epoxide ring (entries16–19). The ring opening of cyclohexene oxide was alsosuccessfully achieved giving 90–92% yields of the desired amino alcohols (entries 20–23).
Encouraged by the above results, we next investigated the ring opening of epoxides with heterocyclic amines such
as pyrazoleand imidazole(Table3, entries 1–7). There are very few reports in the literature for the ring opening of
epoxides with heterocyclic amines.20 These methods require high temperature and pressure. The products obtained are
of pharmaceutical importance
aniline, 2-fluoroaniline, p-anisidine and indoline afforded successfully achieved giving 90–92% yields of the desired
good yields with complete regioselectivity (entries 8–11). Chemoselective aminolysis of epichlorohydrin wasobserved, with desired product resulting from attack atthe less substituted carbon on the epoxide ring (entries16–19). The ring opening of cyclohexene oxide was alsosuccessfully achieved giving 90–92% yields of the desired amino alcohols (entries 20–23).
Encouraged by the above results, we next investigated the ring opening of epoxides with heterocyclic amines such
as pyrazoleand imidazole(Table3, entries 1–7). There are very few reports in the literature for the ring opening of
epoxides with heterocyclic amines.20 These methods require high temperature and pressure. The products obtained are
of pharmaceutical importance
反应环氧丙烷与胺，如16-19 ） 。开环环己烯氧化物也
苯胺， 2 - fluoroaniline ，对氨基苯甲醚和吲哚给予成功实现了让90-92 ％ ，产量达到预期
良好的收益率与完整的区域（参赛作品8月11日） 。 chemoselective胺解环氧氯丙烷wasobserved ，具有理想的产品所造成的攻击atthe少取代碳对环氧环（ entries16 - 19 ） 。开环的环氧环己烷是alsosuccessfully取得了给予90-92 ％的产量预期的氨基醇（作品20日至23日） 。
鼓励由上述结果，我们下一步调查开环环氧化物与杂环胺等
作为pyrazoleand咪唑（ table3 ，参赛作品1-7 ） 。有极少数的报告，在文献上为开环
环氧化合物与杂环amines.20这些方法需要高温度和压力。产品获得
药剂的重要性和因此，温和的议定书是理想的为合成这种异质-氨基醇。
最初，我们研究了开环的各种氧化物，如环氧苯乙烷，环氧丙烷，
环氧氯丙烷和环氧环己烷与吡唑和优异的成绩获得。反应吡唑
与苯乙烯的氧化氮和环氧丙烷提供了92 ％和86 ％收益率，分别为（ entries1和2 ） 。开环
对cyclohexeneoxide和环氧氯丙烷与吡唑提供了理想的氨基醇在良好的收益率（参赛作品
3和4 ） 。该胺解这些氧化物是明年investigatedwith咪唑了良好的收益，在
一系列的83-90 ％的环境条件下（参赛作品5-7 ） 。因此，催化剂Y （下硝酸） 36h2o ，使有效率的耦合
对杂环胺的各种氧化物providingexcellent产量的理想产品
LONG