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来源：百度知道 编辑：UC知道 时间：2024/06/04 14:00:10
Conclusions
On the basis of the photoreactivity, spectroscopy, and spectrometry data, we determined the structure of the new photoproduct to be a nonadjacent cis-anti cyclobutane dimer formed between T2 and T7 with the absolute stereochemistry depicted by structure I (Figure 8B). This is the first interstrand type of cyclobutane dimer to be isolated and characterized in DNA. There is no predictable stable Watson-Crick folded structure of d(GTATCATGAGGTGC) that can explain the high yield formation of this product. On the basis of our mutagenesis and concentration studies, we speculate that the sequence adopts a higher order folded structure at pH 5 by inter- and intramolecular base pairing between strands, which remains to be elucidated. The formation of this interstrand photoproduct also suggests that such type of photoproducts might also form in biologically important higher order DNA structures such as between loops of G-quartet structures in telomeres and promoters and between
On the basis of the photoreactivity, spectroscopy, and spectrometry data, we determined the structure of the new photoproduct to be a nonadjacent cis-anti cyclobutane dimer formed between T2 and T7 with the absolute stereochemistry depicted by structure I (Figure 8B). This is the first interstrand type of cyclobutane dimer to be isolated and characterized in DNA. There is no predictable stable Watson-Crick folded structure of d(GTATCATGAGGTGC) that can explain the high yield formation of this product. On the basis of our mutagenesis and concentration studies, we speculate that the sequence adopts a higher order folded structure at pH 5 by inter- and intramolecular base pairing between strands, which remains to be elucidated. The formation of this interstrand photoproduct also suggests that such type of photoproducts might also form in biologically important higher order DNA structures such as between loops of G-quartet structures in telomeres and promoters and between
结论根据photoreactivity、分光学和光谱数据，我们确定新的photoproduct的结构是nonadjacent同边反cyclobutane二聚体被形成在T2和T7之间以结构描述的绝对立体化学I (图8B)。 这是cyclobutane二聚体的第一个interstrand类型在脱氧核糖核酸将隔绝和描绘的。 没有可能解释这个产品的高出产量形成的可预测的稳定的华森痛性痉挛被折叠的结构d (GTATCATGAGGTGC)。 根据我们的突变形成和集中研究，我们推测序列采取一个高次被折叠的结构在酸碱度5由配对在子线之间的相互和分子内基地，留待去阐明。 这interstrand photoproduct的形成也建议photoproducts的这样类型在生物重要高次脱氧核糖核酸结构在telomeres和促进者在我主题结构也许也形成例如在G四重唱结构之间圈和在子线之间。此中被描述的方法可能用于辨认和映射在解答可能使用作为区别的探针在体内各种各样的折叠的结构之间和的这样photoproducts。 一旦interstrand photoproduct形成结构活动关系更好被了解，它是可以想像的它可能为高次脱氧核糖核酸结构的装配和描述特性也使用为nanotechnological应用。
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