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来源：百度知道 编辑：UC知道 时间：2024/06/25 08:02:48
the genetic components of the RE CDK cyclin p16 tumor suppressor pathway undergo mutational and epigenetic alterations in a wide range of human cancers and serve as critical targets for inactivation by the transforming oncoproteins of several DNA tumor viruses. lung cancer has been a useful model system for these studies as it was hte first tumor to deminstrate an impportant role for RB in the genesis of a common adult malignancy and was also the first human cancer to demonstrate genetic evidence for a multi-compinent RB:p16 tumor suppressor patheway.lung tumorigenesis, however, is a complex disease process that requires longstanding carcinogen exposure in order to acquire longstanding carcinogen exposure in order to acquire somatic alterations at many distinct genetic loci。Understanding the multifunctional proerties of RB to regulate cell prolferationm,differentiation, and apoptosis and how they relate to the sequential accumulation of other clonal gene defects will be essential in or
遗传组成部分稀土激酶细胞周期p16抑癌途径进行突变和表观遗传改变了广泛的人类癌症，并作为重要的目标，失活蛋白的转化的若干DNA的肿瘤病毒。肺癌已成为有用的模型系统研究，因为它是第一个肿瘤hte以deminstrate一个impportant作用，包在一个共同的成因和成人恶性肿瘤也是第一个人类癌症遗传证据证明的多compinent经常预算： p16抑癌patheway.lung肿瘤，但是，是一种复杂的疾病过程，需要长期接触致癌物质，以获得长期的致癌物接触，以获取体改建在许多不同的基因位点。了解多功能proerties的经常预算，以调节细胞prolferationm ，分化和凋亡以及他们如何涉及到连续积累的其他克隆基因缺陷将是至关重要的，以便了解spectific patterms公积金基因失活观察不同亚型的肺癌和fullfill的诺言“分子靶标” therapeutice
关键词retionblastomacyclin依赖性激酶p16INK3
p27kipl蛋白肺癌euroendocrine
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