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来源:百度知道 编辑:UC知道 时间:2024/05/30 22:46:29
Chitosan, when added to the subphase, enhances the competitive
adsorption of the clinical lung surfactant, Survanta, to an albumin covered interface over a narrow concentration range. In direct analogy to chitosan's effects on anionic colloid stability, at the optimal
concentration, the chitosan irreversibly adsorbs to the negatively charged albumin and Survanta, leading to a net neutralization of
charge in the double layer and an elimination of the electrostatic
barrier to Survanta adsorption. However, as the charge distribution on albumin, Survanta and chitosan are not perfectly matched, the
albumin and Survanta surfaces, even at net neutrality, likely have
patches of negative charge remaining on the surfaces that can bind additional chitosan. Hence, on addition of chitosan in excess of that needed to neutralize the surfaces, the net charge in the double layer is reversed, leading to a new positive surface potential and a new, likely different electr

壳聚糖,在加入亚相,提高竞争力
在临床肺表面活性物质,Survanta,吸附覆盖的浓度范围狭窄界面的白蛋白。在直接类比壳聚糖的影响阴离子胶体稳定在最佳,
浓度,壳聚糖不可逆转地吸附到带负电荷的白蛋白和Survanta,导致净中立化
双电荷层和一个静电消除
障碍Survanta吸附。然而,由于对白蛋白,Survanta和壳聚糖的电荷分布都不能完全匹配,
白蛋白和Survanta表面,即使是在网络中立性,很可能
补丁负的表面,能够把更多的壳聚糖的剩余电量。因此,对在该过剩壳聚糖除了需要抵消表面,在双层净电荷正好相反,导致了新的积极面的潜力和新的,可能不同的障碍Survanta静电吸附,在出现的
降低吸附浓度的增加,我们看到