what is your trouble?

你有什么难处吗？

have trouble [简明英汉词典]
v.在...有困难
what's wrong [简明英汉词典]
怎么了
the matter [简明英汉词典]
有问题, 有毛病

你有什么麻烦

你怎么了?

你怎么了？

What's your trouble?
=What's wrong with you?
=What's the matter with you?
你怎么了？/你出了什么事？/你哪里不舒服？

你有什么麻烦?