UC知道急，帮忙翻译下化学文献
来源：百度知道 编辑：UC知道 时间：2024/05/26 12:57:20
Food fortification with a proper zinc compound is an economic and effective strategy to prevent zinc deficiency. BioZn-AAS, a zinc gluconate stabilized with glycine, was compared with zinc sulfate
(reference standard), zinc hydroxide, and zinc gluconate, all of them labeled with 65Zn. This preclinical
study was performed on Sprague-Dawley rats of both sexes, and the administered dose was 85 mg/kg of zinc. Bioavailability studies showed that absorption of BioZn-AAS was not statistically different than absorption from other sources in female rats (25.65% 6 2.20% for BioZn-AAS, 28.24% 6 4.60% for ZnSO4, 24.91% 6 4.02% for Zn[OH]2, and 25.51% 6 2.70% for Zn-gluconate). In the case of the male rats, absorption of BioZn-AAS (27.97% 6 4.20%) was higher (P,0.05) than that from the other compounds (23.15% 6 2.90% for ZnSO4, 22.62% 6 3.90% for Zn[OH]2, and 22.30% 6 3.90% for
Zn-gluconate). Biodistribution studies
(reference standard), zinc hydroxide, and zinc gluconate, all of them labeled with 65Zn. This preclinical
study was performed on Sprague-Dawley rats of both sexes, and the administered dose was 85 mg/kg of zinc. Bioavailability studies showed that absorption of BioZn-AAS was not statistically different than absorption from other sources in female rats (25.65% 6 2.20% for BioZn-AAS, 28.24% 6 4.60% for ZnSO4, 24.91% 6 4.02% for Zn[OH]2, and 25.51% 6 2.70% for Zn-gluconate). In the case of the male rats, absorption of BioZn-AAS (27.97% 6 4.20%) was higher (P,0.05) than that from the other compounds (23.15% 6 2.90% for ZnSO4, 22.62% 6 3.90% for Zn[OH]2, and 22.30% 6 3.90% for
Zn-gluconate). Biodistribution studies
和上文重复的资料我不再翻译，我的推测是正确的，你用的是同位素标记的方法。另外下面很多数字“6”可能是平均值正负偏差的数学符号不能被正常显示造成的，再次用“加减”予以更正。
临床前期研究使用雌雄两性的正常大鼠，给药剂量是85 mg锌/kg体重。 生物可利用性研究表明，雌鼠对生物氨基酸锌的吸收与其他来源的锌的吸收在统计上无显著性差异 (生物氨基酸锌：25.65%加减2.20%；硫酸锌：28.24%加减4.60% ；氢氧化锌：24.91%加减4.02%；葡萄糖酸锌：25.51%加减2.70%)。雄鼠对生物氨基酸锌的吸收 (27.97%加减4.20%)在5％差异显著性水平上高于其他含锌化合物 (硫酸锌：23.15%加减2.90%；氢氧化锌：22.62%加减3.90%；葡萄糖酸锌：22.30%加减3.90%。生物体内分布研究表明来自生物氨基酸锌的锌元素和其他来源的锌元素代谢途径相同。毒力研究用50只雌鼠和50只雄鼠。雌鼠的口服致死中量(LD50)是2000 mg/kg，雄鼠是1900 mg/kg。因此，我们得出结论，生物氨基酸锌用于食物强化或饮食添加剂有足够的优点。
杂志名称：《Nutrition》
年代：2000
期号：16
页码：762–766
版权所有：Elsevier Science Inc. 2000