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来源：百度知道 编辑：UC知道 时间：2024/05/14 04:40:18
AUC 的增加低于给药剂量的增加，提示吸收存在受剂量限制的饱和趋势。由于原形药的单一羟基化将仍然保留化学分子的HDAC抑制活性作用，从而可能使药效和毒理都将与这些体内代谢物相关
高剂量组见少数 散在性局灶性 点灶状轻度心肌纤维呈嗜酸性变；胸腺轻度萎缩，皮质轻度变薄；脾小体少数淋巴细胞核固缩碎裂；淋巴结淋巴滤泡少数淋巴细胞核固缩碎裂，骨髓腔分叶核粒细胞轻度减少；肝少数点灶状坏死，伴出血；肾脏远曲小管轻度扩张，上皮细胞轻度变性；睾丸少数曲细精管生精上皮变薄，精原细胞轻度变性，卵巢成熟卵泡部分颗粒细胞变性。
CS—055吸收速度相对比较迅速，但AUC的增加均低于给药剂量的增加，提示吸收可能存在受剂量限制的饱和趋势。体内代谢主要表现为在原形药吡啶环上的氧化代谢。由于原形药的单一羟基化将仍然保留化学分子的HDAC抑制活性作用，从而可能使CS—055的药效和毒理都将与这些体内代谢物相关
高剂量组分别见少数散在性局灶性点灶状轻度心肌纤维呈嗜酸性变；胸腺轻度萎缩，皮质轻度变薄；脾小体少数淋巴细胞核固缩碎裂；淋巴结淋巴滤泡少数淋巴细胞核固缩碎裂，骨髓腔分叶核粒细胞轻度减少；肝少数点灶状坏死，伴出血；肾脏远曲小管轻度扩张，上皮细胞轻度变性；睾丸少数曲细精管生精上皮变薄，精原细胞轻度变性，卵巢成熟卵泡部分颗粒细胞变性；其他器官组织未见明显病变。
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AUC increased less than the dose increased, suggesting that the existence of absorption dose limit of saturation trend. The prototype of a single-hydroxylation of chemical elements would still retain the role of HDAC inhibition activity, which may have efficacy and toxicity with these in vivo metabolism of related
High-dose group see in a few scattered foci of the focal points of mild myocardial fibers were eosinophilic change; Mild thymus atrophy, mild cortical thinning; Body minority spleen lymphocytes karyopyknosis fragmentation; Lymph node lymphocytes in a lymph follicles karyopyknosis cracking the bone marrow cavity of nuclear mild leukocyte reduction; Liver few points focus of necrosis with hemorrhage; kidney distal tubules mild expansion, epithelial cells mild degeneration; testicular minority Qu seminiferous tubules spermatogenic epithelium thinning, spermatogonia mild degeneration, ovarian granulosa cells of mature follicles degeneration.
CS-055 is relatively ra