UC知道高分求助翻译成英语
来源：百度知道 编辑：UC知道 时间：2024/05/10 10:10:10
目的：研究阿片类药物对家兔小肠平滑肌运动功能的影响并初步探讨其可能作用机制。
方法：健康新西兰兔56只，按实验方法的不同随机分为在体实验组和离体实验组。在体实验组新西兰兔17只，随机分为对照组（A组）8例，实验组（B组）9例。通过胃管分别注入生理盐水或吗啡混合墨汁的液体共5毫升，30分钟后急性处死测量墨汁在肠管的推进距离，计算墨汁在小肠的推进率。离体实验组新西兰兔28只，随机分为对照组（C组）、低浓度吗啡组（L组）、中浓度吗啡组（M组）、高浓度吗啡组（H组）、纳洛酮加中浓度吗啡组（NM组）、阿托品加中浓度吗啡组（AM组），阿托品和纳洛酮加中浓度吗啡组（CM组），每组4只。家兔急性处死后制备离体小肠肠管灌流模型，分别依照各组设计的不同浓度药物或者不同药物预处理后进行离体肠管恒温恒速灌流，待灌流平衡后利用Medlab生物信号采集系统采集离体肠管纵、环形肌张力和频率变化曲线，分析其对离体小肠肠管纵、环形肌收缩的张力和频率变化。
结果：(1)小肠推进率比较: 与A组比较，B组小肠推进率明显降低，差异有统计学意义 (P<0.05)。（2）不同浓度吗啡对离体肠管纵、环形肌张力和频率影响比较：M组、H组肠管纵形肌张力明显高于C组，差异有统计学意义(P<0.05)，各组频率变化比较差异无统计学意义。L组、M组、H组肠管环形肌张力明显高于C组（P<0.05），各组频率比较差异无统计学意义。（3）不同药物作用后中浓度吗啡对离体肠管纵形肌张力和频率的影响比较：与M组比较，NM组、AM组、CM组肠管纵形肌张力明显降低（P<0.05）；与C组比较，CM组肠管纵形肌张力明显降低（P<0.05）。AM组、CM组肠管纵形肌频率与M组和C组比较均明显降低（P<0.05）。（4）不同药物作用后中浓度吗啡对离体肠管环形肌张力和频率的影响比较：与M组比较，NM组、AM组、CM组肠管环形肌张力明显降低（P<0.05）；与C组比较，AM组、CM组肠管纵形肌张力明显降低（P<0.05）。AM组、CM组肠管环形肌频
Objective: To study the opioid drugs on the rabbit intestinal smooth muscle function and to explore the impact of its possible mechanism.
Methods: New Zealand rabbits 56, according to the different experimental methods were randomly divided into groups and in vivo experiments in vitro experimental group. In the experimental group of 17 New Zealand white rabbits were randomly divided into two groups (group A) in 8 cases, the experimental group (group B) 9. Saline were injected through the tube or liquid morphine mixed ink of 5 ml, 30 minutes after the death of acute intestinal measuring the advance of ink in the distance, in the ink of the rate of intestinal advance. In vitro experimental group 28 New Zealand white rabbits were randomly divided into control group (group C), low concentrations of morphine group (Group L), the concentration of morphine group (group M), high concentrations of morphine group (Group H), satisfied Luo increase in the concentration of one morphine gro