UC知道求翻译08年最新生物学资料4 有强人不～
来源：百度知道 编辑：UC知道 时间：2024/05/22 19:00:27
Endothelial nitric oxide synthase intron 4a/b polymorphism and early atherosclerotic changes in hypopituitary GH-deficient adult patients.
OBJECTIVE: Endothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism is associated with plasma NO concentrations and coronary artery disease/hypertension in various populations. GH deficiency in adulthood predisposes to reduced NO concentrations and premature atherosclerosis. Our aim was to determine whether intron 4a/b polymorphism of eNOS gene influences endothelial function and early atherosclerotic changes in GH-deficient hypopituitary patients. DESIGN: Thirty-three hypopituitary GH-deficient patients on conventional replacement therapy other than GH and 43 age-, sex-, and body mass index (BMI)-matched controls were studied in this cross-sectional case-control study. METHODS: Early atherosclerotic changes were determined by flow-mediated dilation (FMD) of brachial artery and carotid artery intima-media thickness (IMT). eNOS4a/b poly
OBJECTIVE: Endothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism is associated with plasma NO concentrations and coronary artery disease/hypertension in various populations. GH deficiency in adulthood predisposes to reduced NO concentrations and premature atherosclerosis. Our aim was to determine whether intron 4a/b polymorphism of eNOS gene influences endothelial function and early atherosclerotic changes in GH-deficient hypopituitary patients. DESIGN: Thirty-three hypopituitary GH-deficient patients on conventional replacement therapy other than GH and 43 age-, sex-, and body mass index (BMI)-matched controls were studied in this cross-sectional case-control study. METHODS: Early atherosclerotic changes were determined by flow-mediated dilation (FMD) of brachial artery and carotid artery intima-media thickness (IMT). eNOS4a/b poly
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要好好学习哦．．．
加油．．．
内皮细胞的氧化一氮合酶基因内区4a/b多形性和在hypopituitary GH短少成人患者上的早期的动脉粥样硬化的变化。
OBJECTIVE ： 内皮细胞的氧化一氮合酶(eNOS)基因内区4a/b多形性同等离子联系在一起没有集中和冠状动脉病或者高血压以各种各样的人口。 在成年的GH缺乏不预先处理减少了集中和过早的动脉粥样硬化。 我们的目标将确定eNOS基因基因内区4a/b多形性是否影响内皮细胞的作用和在GH短少hypopituitary患者上的早期的动脉粥样硬化的变化。 设计： 常规替换疗法的三十三名hypopituitary GH短少患者除GH之外和43在这次代表性情形控制研究中变老，性和身体容积指数(BMI) -被匹配的控制被学习了。 方法： 早期的动脉粥样硬化的变动取决于流动斡旋的扩张(FMD)肱动脉和颈动脉内膜媒介厚度(IMT)。 PCR查出eNOS4a/b多形性。 结果： Hypopituitary患者安排显着更加高级的总或低密度脂蛋白胆固醇和肥胖大量和更低的IGF-I集中比较控制。 IMT是显着高在患者(0.777+/-0.23对0.639+/-0.17 mm、P或者=27.9 kg/m (2)是IMT>或=0.65 mm的重大独立预报因子。 结论： 强制的数据不是显然的建议eNOS4a/b多形性修改在GH短少情况的动脉粥样硬化的过程。 一项大情形控制研究是需要的证实我们的研究结果