UC知道高分求医学类专业翻译！急！！！！！在线等4
来源：百度知道 编辑：UC知道 时间：2024/06/24 13:51:35
There are a number of lines of evidence supporting the hypothesis that mitochondrial dysfunction is a characteristic of human aging in skeletal muscle. Studies have found lower mitochondrial enzyme activity, lower mitochondrial protein synthesis, an increase in mitochondrial DNA (mtDNA) deletions, a reduction in mtDNA content，and an increase in oxidative stress, in skeletal muscle from older adults. Importantly, a strong association has been found between skeletal muscle atrophy and the accumulation of mtDNA mutations and mitochondrial dysfunction in humans. Although various aspects of the “mitochondrial theory of aging” have come under increasing scrutiny in the last several years，two recent reports that transgenic animals with a mutation in polymerase show many of the characteristics of human aging, suggest that mitochondria may be involved in the pathogenesis of aging. Further support for a role of mitochondrial dysfunction in aging has come from transcriptome profiling studies in b
有许多证据支持这一假设的线粒体功能障碍的一个特点是人类衰老骨骼肌。研究发现线粒体酶活性降低，降低线粒体蛋白质的合成，增加线粒体DNA （ mtDNA ）缺失，减少线粒体DNA含量，并增加氧化应激，骨骼肌由老年人。重要的是，一个强有力协会之间已发现骨骼肌萎缩和积累的线粒体DNA突变与线粒体功能障碍的人。虽然各方面的“线粒体老化理论”最近受到越来越多在过去几年里，最近的两项报告说，转基因动物的基因突变的聚合酶查看的许多特点人类衰老，表明线粒体可能参与发病机制中的老化。进一步支持作用，线粒体功能障碍的老化来自转录貌相研究动物和人类。研究人类使用芯片还发现低丰度表达骨骼肌的组成部分线粒体和能源高产途径老年人与年轻人。最近的一项研究报告说，协调下调许多基因参与了线粒体结构和功能的一些组织。与此相反，一项研究报告“的签署sarcopenia分子”的男子没有报告任何行动或下调基因物种参与或者线粒体或能源高产途径。我们的数据增加了后者的研究在人类在许多方面。
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