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来源：百度知道 编辑：UC知道 时间：2024/06/08 09:49:39
Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes
摘要: Our work has shown that certain ruthenium(II) arene complexes exhibit promising anticancer activity in vitro and in vivo. The complexes are stable and water-soluble, and their frameworks provide considerable scope for optimising the design, both in terms of their biological activity and for minimising side-effects by variations in the arene and the other coordinated ligands. Initial studies on amino acids and nucleotides suggest that kinetic and thermodynamic control over a wide spectrum of reactions of Ru(II) arene complexes with biomolecules can be achieved. These Ru( II) arene complexes appear to have an altered profile of biological activity in comparison with metal-based anticancer complexes currently in clinical use or on clinical trial.
摘要: Our work has shown that certain ruthenium(II) arene complexes exhibit promising anticancer activity in vitro and in vivo. The complexes are stable and water-soluble, and their frameworks provide considerable scope for optimising the design, both in terms of their biological activity and for minimising side-effects by variations in the arene and the other coordinated ligands. Initial studies on amino acids and nucleotides suggest that kinetic and thermodynamic control over a wide spectrum of reactions of Ru(II) arene complexes with biomolecules can be achieved. These Ru( II) arene complexes appear to have an altered profile of biological activity in comparison with metal-based anticancer complexes currently in clinical use or on clinical trial.
有机金属化学，生物和医学：钌配合物的抗癌芳烃
摘要：我们的工作表明，某些钌（II）芳烃配合物的前景表现出体外抗癌活性及体内。配合物稳定，水溶性，其框架提供了优化设计，无论是在其生物活性条款和减少副作用很大的余地，在变化的芳烃和其他协调配体的影响。对氨基酸和核苷酸的初步研究表明，动力学和热力学主持召开了反应钌（Ⅱ）配合物与生物分子芳烃广泛的控制可以实现的。这些钌（II）芳烃配合物似乎是在与金属相比，生物活性改变的文件为基础的，目前在临床使用或临床试验抗癌物。