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来源：百度知道 编辑：UC知道 时间：2024/06/17 23:12:12
CHAMPAIGN, Ill. — Scientists have found a way to trick cancer cells into committing suicide. The novel technique potentially offers an effective method of providing personalized anti-cancer therapy.
Most living cells contain a protein called procaspase-3, which, when activated, changes into the executioner enzyme caspase-3 and initiates programmed cell death, called apoptosis. In cancer cells, however, the signaling pathway to procaspase-3 is broken. As a result, cancer cells escape destruction and grow into tumors.
“We have identified a small, synthetic compound that directly activates procaspase-3 and induces apoptosis,” said Paul J. Hergenrother, a professor of chemistry at the University of Illinois at Urbana-Champaign and corresponding author of a paper to be posted online this week ahead of regular publication by the journal Nature Chemical Biology. “By bypassing the broken pathway, we can use the cells’ own machinery to destroy themselves.”
To fi
Most living cells contain a protein called procaspase-3, which, when activated, changes into the executioner enzyme caspase-3 and initiates programmed cell death, called apoptosis. In cancer cells, however, the signaling pathway to procaspase-3 is broken. As a result, cancer cells escape destruction and grow into tumors.
“We have identified a small, synthetic compound that directly activates procaspase-3 and induces apoptosis,” said Paul J. Hergenrother, a professor of chemistry at the University of Illinois at Urbana-Champaign and corresponding author of a paper to be posted online this week ahead of regular publication by the journal Nature Chemical Biology. “By bypassing the broken pathway, we can use the cells’ own machinery to destroy themselves.”
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既然你要求了那么：
香槟,Ill--科学家已经找到了一条进入癌细胞自杀的把戏. 新技术带来的潜在的有效方法,提供个性化抗癌疗法. 最活细胞含有蛋白质称为酶原三日,当启动 转变成操刀酶caspase-3和启动程序性细胞死亡,所谓凋亡. 在癌细胞,但是,信号通路以酶原3破. 由于癌细胞逃脱毁灭和成长为肿瘤. "我们发现一小、合成化合物,直接酶原激活3、诱导说:"保罗Jhergenrother, 化学系教授在伊利诺大学厄巴纳-香槟和相应的文件将提交本周在网上提前发表了经常性JOURNAL化学生物学. "绕过碎通路,我们可以利用细胞自身毁灭自己机器" 找到大院 一个叫酶原激活化合物(PAC-3型1),hergenrother,在与同事的脲一、汉城国立大学 和全国毒理学研究中心、 化合物筛选两万多元结构的转换酶原3成caspase-3的. 研究人员检验了复方的疗效和细胞培养三个鼠标型号癌症. 测试术与威廉helferich, 教授在食品科学和人类营养的脲一、 并明-前南倬在汉城国立大学. 研究人员还发现爱国者231杀死癌细胞肿瘤来自当地医院. 细胞死亡的水平呈酶原存在于细胞3、 更多酶原-3造成细胞死亡浓度较低的爱国者1. "这是第一批在怎么有能力直接有机化合物激活酶刽子手"hergenrother, 谁也属生物基因组研究所在对脲导"的潜在效益帐等化合物-1能提前预测, 病人可以选择接受治疗以金额酶原3发现自己的肿瘤细胞. "这种个性化疗法药战略,依靠优惠给普通细胞毒素、 研究人员说,将来可以抗癌疗法. 工作是由美国国家科学基金会、国家卫生研究所、伊利诺大学.
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