UC知道谁能帮我翻译一下这篇文献！
来源：百度知道 编辑：UC知道 时间：2024/05/25 02:24:00
Mark R. Prausnitz*
School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332-0100, USA
Received 9 September 2003; accepted 13 October 2003
Abstract
The success of transdermal drug delivery has been severely limited by the inability of most drugs to enter the skin at
therapeutically useful rates. Recently, the use of micron-scale needles in increasing skin permeability has been proposed and
shown to dramatically increase transdermal delivery, especially for macromolecules. Using the tools of the microelectronics
industry, microneedles have been fabricated with a range of sizes, shapes and materials. Most drug delivery studies have
emphasized solid microneedles, which have been shown to increase skin permeability to a broad range of molecules and
nanoparticles in vitro. In vivo studies have demonstrated delivery of oligonucleotides, reduc
我不逐字翻译了，大意是：
经由皮肤吸收的药物传导系统受到了大部分的药物无法以有治疗效果的速率进入皮肤的限制。最近，有人提出用微米大小的针头来增加皮肤的渗透性并且证实此法对大分子进入皮肤有极佳的效果。利用微米电子业界所使用的工具，微米针头可以用许多材料制作，并制成各种大小和形状。大部份的药物传导研究都著重於固体的微米针头，并且已经在实验室里证实可以增加皮肤对不同大小的分子和奈米分子的渗透性。在活体试验中，则已成功证实了透过皮肤完成寡核苷酸的吸收，胰岛素对血糖的降低，以及蛋白质和去氧核糖核酸疫苗的免疫反应。
（太多了，下次吧）
For these studies, needle arrays have been used to
pierce holes into skin to increase transport by diffusion or iontophoresis or as drug carriers that release drug into the skin from a
microneedle surface coating. Hollow microneedles have also been developed and shown to microinject insulin to diabetic rats.
To address practical applications of microneedles, the ratio of microneedle fracture force to skin insertion force (i.e. margin of
safety) was found to be optimal for needles with small tip radius and large wall thickness. Microneedles inserted into the skin of
human subjects were reported as painless. Together, these results suggest that microneedles represent a promising techn