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来源：百度知道 编辑：UC知道 时间：2024/06/01 06:47:42
白桦酸和白桦素及他们衍生物具有肿瘤抑制作用和抗HIV作用，国内外都做了大量的结构修饰和药理活性测的工作，以寻找活性更强，毒副作用更小的新化合物。
从对白桦酸和白桦素及他们衍生物的构效关系研究中可知，其C-3，C-19和C-28 三个部位是与生物活性密切相关的部位，对这些部位的结构改造不仅可以提高化合物的溶解性，增加生物利用度，还可以降低毒性。
Birch acid compounds are a class of anti-cancer and anti-HIV activity of natural products, its structure transformation, and pharmacological research reports at home and abroad more common in the literature.
Birch acid and birch-and their derivatives have cancer and inhibit anti-HIV effect, at home and abroad have done a lot of structure modification and pharmacological activity measurement work to find more activity, more minor side effects of new compounds.
Birch from the birch-and acid and their derivatives QSAR study indicates that its C-3, C-19 and C-28 three parts and biological activity is closely related to the location of these sites not only the structural transformation Compounds can improve the solubility, increasing bioavailability, can also reduce the toxicity.
White birch acids compound is 1 type have anti-cancer with anti- HIV activity of natural product, as to it's structure reformation and pharmacology study of the report way is see in domesti